Publication

Process systems engineering plays a critical role in the process design of continuous tablet manufacturing, which is a novel technology. Numerous researchers have worked on process simulation using both mechanistic and data-driven models. Toward efficient process design, it is important to select appropriate modeling techniques and interpret the results based on knowledge of pharmaceutical science. This seminar will give different types of modeling studies in continuous tablet manufacturing, which I have performed through my Ph.D. at the University of Tokyo and my postdoctoral research at Ghent University. As an example of mechanistic modeling, population balance models have been applied to the simulation of particle size distributions in wet granulation. Hybrid and surrogate modeling approaches will extend the applicability of models to different active pharmaceutical ingredients and real-time release testing. Furthermore, an in-depth understanding of material properties as well as unit operations can help with model development and interpretation.