Publication

Academic papers

2024

• "Roles of mechanistic, data-driven, and hybrid modeling approaches for pharmaceutical process design and operation"
  Mohamed Rami Gaddem, Junu Kim, Kensaku Matsunami, Yusuke Hayashi, Sara Badr, Hirokazu Sugiyama
  Current Opinion in Chemical Engineering 44, 101019 (2024).

  • URL
  • DOI: 10.1016/j.coche.2024.101019
• "Scenario Analysis of Vaccine Supply for COVID-19 in Japan Using Mathematical Models of Infectious Diseases"
  Junu Kim, Kensaku Matsunami, Yusuke Ichida, Kozue Okamura, Sara Badr, Hirokazu Sugiyama
  Journal of Chemical Engineering of Japan 57, 1, 2313318 (2024).

  • URL
  • DOI: 10.1080/00219592.2024.2313318
• "Analysis of the effect of formulation properties and process parameters on granule formation in twin-screw wet granulation"
  Michiel Peeters, Ana Alejandra Barrera Jiménez, Kensaku Matsunami, Michael Ghijs, Eduardo Dos Santos Schultz, Mina Roudgar, Tamas Vigh, Fanny Stauffer, Ingmar Nopens, Thomas De Beer
  International Journal of Pharmaceutics 650, 123671 (2024).

  • URL
  • DOI: 10.1016/j.ijpharm.2023.123671

2023

• "T-shaped partial least squares for high-dosed new active pharmaceutical ingredients in continuous twin-screw wet granulation: Granule size prediction with limited material information"
  Kensaku Matsunami, Jonathan Meyer, Martin Rowland, Neil Dawson, Thomas De Beer, Daan Van Hauwermeiren
  International Journal of Pharmaceutics 646, 123481 (2023).

  • URL
  • DOI: 10.1016/j.ijpharm.2023.123481
• "Validation of model-based design of experiments for continuous wet granulation and drying"
  Kensaku Matsunami*, Tuur Vandeputte*, Ana Alejandra Barrera Jiménez, Michiel Peeters, Michael Ghijs, Daan Van Hauwermeiren, Fanny Stauffer, Eduardo dos Santos Schultz, Ingmar Nopens, Thomas De Beer (*shared first authorship)
  International Journal of Pharmaceutics 646, 123493 (2023).

  • URL
  • DOI: 10.1016/j.ijpharm.2023.123493
• "Development of concentration prediction models for personalized tablet manufacturing using near-infrared spectroscopy"
  Yusuke Hayashi, Saho Okazaki, Kensaku Matsunami, Kazuya Tanabe, Takuya Nagato, Hirokazu Sugiyama
  Chemical Engineering Research and Design 199, 507–514 (2023).

  • URL
  • DOI: 10.1016/j.cherd.2023.10.009
• "Exploring the effect of raw material properties on continuous twin-screw wet granulation manufacturability"
  Michiel Peeters, Ana Alejandra Barrera Jiménez, Kensaku Matsunami, Daan Van Hauwermeiren, Fanny Stauffer, Lærke Arnfast, Tamas Vigh, Ingmar Nopens, Thomas De Beer
  International Journal of Pharmaceutics 645, 123391 (2023).

  • URL
  • DOI: 10.1016/j.ijpharm.2023.123391
• "Partial least squares regression to calculate population balance model parameters from material properties in continuous twin-screw wet granulation"
  Ana Alejandra Barrera Jiménez*, Kensaku Matsunami*, Daan Van Hauwermeiren, Michiel Peeters, Fanny Stauffer, Eduardo dos Santos Schultz, Ashish Kumar, Thomas De Beer, Ingmar Nopens (*shared first authorship)
  International Journal of Pharmaceutics 640, 123040 (2023).

  • URL
  • DOI: 10.1016/j.ijpharm.2023.123040
• "Evaluation of the influence of material properties and process parameters on granule porosity in twin-screw wet granulation"
  Michiel Peeters, Ana Alejandra Barrera Jiménez, Kensaku Matsunami, Fanny Stauffer, Ingmar Nopens, Thomas De Beer
  International Journal of Pharmaceutics 641, 123010 (2023).

  • URL
  • DOI: 10.1016/j.ijpharm.2023.123010
• "Linking material properties to 1D-PBM parameters towards a generic model for twin-screw wet granulation"
  Ana Alejandra Barrera Jiménez*, Kensaku Matsunami*, Daan Van Hauwermeiren, Michiel Peeters, Fanny Stauffer, Eduardo dos Santos Schultz, Ashish Kumar, Thomas De Beer, Ingmar Nopens (*shared first authorship)
  Chemical Engineering Research and Design 193, 713–724 (2023).

  • URL
  • DOI: 10.1016/j.cherd.2023.04.009
• "Model development and calibration of two-dimensional population balance model for twin-screw wet granulation based on particle size distribution and porosity"
  Ana Alejandra Barrera Jiménez*, Kensaku Matsunami*, Michael Ghijs, Daan Van Hauwermeiren, Michiel Peeters, Fanny Stauffer, Thomas De Beer, Ingmar Nopens (*shared first authorship)
  Powder Technology 419, 118334 (2023).

  • URL
  • DOI: 10.1016/j.powtec.2023.118334
• "Surrogate modeling of dissolution behavior toward efficient design of tablet manufacturing processes"
  Kensaku Matsunami, Tomohiro Miura, Keita Yaginuma, Shuichi Tanabe, Sara Badr, Hirokazu Sugiyama
  Computers & Chemical Engineering 171, 108141 (2023).

  • DOI: 10.1016/j.compchemeng.2023.108141

2021

• "Analysis of the effects of process parameters on start-up operation in continuous wet granulation"
  Kensaku Matsunami, Alexander Ryckaert, Michiel Peeters, Sara Badr, Hirokazu Sugiyama, Ingmar Nopens, Thomas De Beer
  Processes 9, 9, 1502 (2021).

  • DOI: 10.3390/pr9091502
• "Determination of critical decision points for COVID-19 measures in Japan"
  Junu Kim*, Kensaku Matsunami*, Kozue Okamura*, Sara Badr, Hirokazu Sugiyama (*shared first authorship)
  Scientific Reports 11, 16416 (2021).

  • URL
  • DOI: 10.1038/s41598-021-95617-z

2020

• "Superstructure-based process synthesis and economic assessment under uncertainty for solid drug product manufacturing"
  Kensaku Matsunami, Fabian Sternal, Keita Yaginuma, Shuichi Tanabe, Hiroshi Nakagawa, Hirokazu Sugiyama
  BMC Chemical Engineering 2, 6 (2020).

  • URL
  • DOI: 10.1186/s42480-020-0028-2
• "Determining key parameters of continuous wet granulation for tablet quality and productivity: A case in ethenzamide"
  Kensaku Matsunami, Takuya Nagato, Koji Hasegawa, Hirokazu Sugiyama
  International Journal of Pharmaceutics 579, 119160 (2020).

  • URL
  • DOI: 10.1016/j.ijpharm.2020.119160

2019

• "A large-scale experimental comparison of batch and continuous technologies in pharmaceutical tablet manufacturing using ethenzamide"
  Kensaku Matsunami, Takuya Nagato, Koji Hasegawa, Hirokazu Sugiyama
  International Journal of Pharmaceutics 559, 210–219 (2019).

  • URL
  • DOI: 10.1016/j.ijpharm.2019.01.028

2018

• "Decision support method for the choice between batch and continuous technologies in solid drug product manufacturing"
  Kensaku Matsunami, Takuya Miyano, Hiroaki Arai, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama
  Industrial & Engineering Chemistry Research 57, 30, 9798–9809 (2018).

  • URL
  • DOI: 10.1021/acs.iecr.7b05230